Featured Publications

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Featured Publications


Measurement of the mid-infrared absorption spectra of ethylene (C2H4) and other molecules at high temperatures and pressures

Journal of Quantitative Spectroscopy & Radiative Transfer | October 18, 2018 | DOI: 10.1016/j.jqsrt.2018.10.030| C.L. Strand, et al

High-temperature and high-pressure gases exist in a wide range of natural and man-made environments, but there is a lack of experimental absorption data for these conditions.  Researchers at Stanford University used an improved widely-tunable mid-IR laser with tuning speeds up to 30,000 cm-1 per second to measure full vibrational bands in shock-tube test gases.  This data is compared to existing experimental and ab-initio databases.  Example gases studied in this manner include propane, 1-butene, 1,3-butadiene and methanol at 1000 K and 2.3 atm.

Imaging-based molecular barcoding with pixelated dielectric metasurfaces

Science | June 8, 2018 | DOI: 10.1126/science.aas9768 | H. Altug, et al

Researchers at EPFL (Lausanne, Switzerland) recently developed a novel nanophotonic sensor array which could someday propane in routine environmental sensing and point-of-care diagnostics. The new image-based sensor leverages wide-field QCL imaging and functionalized nanofabricated metasurfaces to perform massively parallel sensing of protein and polymer mixture monolayers.

Quantum Cascade Laser-Based Infrared Microscopy for Label-Free and Automated Cancer Classification in Tissue Sections

Scientific Reports | May 16, 2018 | DOI: 10.1038/s41598-018-26098-w | K. Gerwert et al

Researchers at the Ruhr University Bochum (Bochum, Germany) took a major step towards the clinical translation of mid-IR imaging. In a 110 patient feasibility study, the researchers used wide-field QCL microscopy combined with machine learning to automatically detect Stage II and III colorectal cancer in large (cm) unstained biopsied tissue sections in less than 30 minutes. The study results showing 96% sensitivity and 100% specificity were found to be independent of instrument and operator and were achieved without the use of tissue microarrays.